Science teacher Ryland Grace (Ryan Gosling) wakes up on a spaceship light years from home with no recollection of who he is or how he got there. As his memory returns, he begins to uncover his mission: solve the riddle of the mysterious substance causing the sun to die out. He must call on his scientific knowledge and unorthodox ideas to save everything on Earth from extinction… but an unexpected friendship means he may not have to do it alone.

A lonely Frankenstein (Bale) travels to 1930s Chicago to ask groundbreaking scientist Dr. Euphronious (five-time Oscar nominee Annette Bening) to create a companion for him. The two revive a murdered young woman and The Bride (Buckley) is born. What ensues is beyond what either of them imagined: Murder! Possession! A wild and radical cultural movement! And outlaw lovers in a wild and combustible romance!